Browsing by Author "Simón, Felipe"

Now showing items 1-5 of 5

    • Endotoxin induces fibrosis in vascular endothelial cells through a mechanism dependent on transient receptor ... 
      Echeverría, César; Montorfano, Ignacio; Hermosilla, Tamara; Armisen Yáñez, Ricardo; Velásquez, Luis A.; Caballero Verrugio, Claudio; Varela Lekanda, Diego; Simón, Felipe (PLOS One, 2014)
      The pathogenesis of systemic inflammatory diseases, including endotoxemia-derived sepsis syndrome, is characterized by endothelial dysfunction. It has been demonstrated that the endotoxin lipopolysaccharide (LPS) induces ...
    • Excess iodide induces an acute inhibition of the sodium/iodide symporter in thyroid male rat cells by ... 
      Arriagada, Alejandro A.; Albornoz, Eduardo; Opazo, María Cecilia; Becerra, Álvaro; Vidal, Gonzalo; Fardella, Carlos; Michea Acevedo, Luis; Carrasco, Nancy; Simón, Felipe; Elorza, Álvaro A.; Bueno, Susan M.; Kalergis, Alexis M.; Riedel, Claudia A. (Endocrine Society, 2015)
      Na+/I- symporter (NIS) mediates iodide (I-) uptake in the thyroid gland, the first and rate-limiting step in the biosynthesis of the thyroid hormones. The expression and function of NIS in thyroid cells is mainly regulated ...
    • Multifunctional polymeric nanoparticles doubly loaded with SPION and ceftiofur retain their physical and ... 
      Solar, Paula; González Moraga, Guillermo; Vilos, Cristian; Herrera, Natalia; Juica, Natalia; Moreno, Mabel; Simón, Felipe; Velásquez, Luis (BIOMED CENTRAL, 2015)
      Background: Advances in nanostructure materials are leading to novel strategies for drug delivery and targeting, contrast media for magnetic resonance imaging (MRI), agents for hyperthermia and nanocarriers. Superparamagnetic ...
    • Redox-dependent effects in the physiopathological role of bile acids 
      Orozco Aguilar, Josué; Simón, Felipe; Cabello Verrugio, Claudio (Hindawi, 2021)
      Bile acids (BA) are recognized by their role in nutrient absorption. However, there is growing evidence that BA also have endocrine and metabolic functions. Besides, the steroidal-derived structure gives BA a toxic potential ...
    • The critical role of oxidative stress in sarcopenic obesity 
      González, Andrea; Simón, Felipe; Achiardi, Óscar; Vilos, Cristian; Cabrera, Daniel; Cabello Verrugio, Claudio (Hindawi, 2021)
      Sarcopenic obesity (SO) is a combination of obesity and sarcopenia that primarily develops in older people. Patients with SO have high fat mass, low muscle mass, low muscle strength, and low physical function. SO relates ...